Mauricio Pochettino will have to shuffle his Tottenham team Tuesday night as Spurs has been hit with a flurry of injuries before the Champions League tie.
The Argentine's team is in Cyprus for the second game in Group H, facing Apoel Nicosia while Jurgen Klopp's Liverpool and Pep Guardiola's Manchester City are also in action.
Pochettino has known he will be without midfielder Dele Alli and central defender Jan Vertonghen due to suspension, but is missing key players due to injury.
Alli's absence is even more concerning for Pochettino as he will be without Danish playmaker Christian Eriksen due to illness.
Moussa Dembele is unlikely to feature after getting a knock to his ankle during Spurs' 3-2 win over West Ham at the London Stadium on Sunday. Victor Wanyama remains on the sidelines with a knee injury.
Erik Lamela has not played since October 2016 due to a hip injury, and will not be back for the trip to Cyprus, nor will left-back Danny Rose, who has been out for eight months.
Ahead of Manchester City's Group F match against Shakhtar Donetsk, Guardiola's is sweating over the fitness of Benjamin Mendy, the City left-back signed from Monaco in the summer who has eased into the Premier League. The Frenchman limped off during City's 5-0 win over Crystal Palace at the weekend.
Guardiola knows he will be without club captain Vincent Kompany due to a calf strain. The Belgian center back has not played since August, following a 9-0 win for his country over Gibraltar.
After Ilkay Gundogan's 10-month return from an anterior cruciate ligament injury in his right knee, the German midfielder suffered a sprain to his left knee in a the Carabao Cup last week. Gundogan is not expected to be available for Tuesday.
Liverpool has no new injury concerns ahead of its game against Spartak Moscow, but Klopp is still without Adam Lallana due to a problem with his thigh and Nathaniel Clyne who has a hamstring issue.
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