Poor people have the worst lung cancer survival rates, according to new research.
Their tumors are diagnosed at a later stage, when radiotherapy and chemotherapy are often ineffective.
The findings shed fresh light on why lung cancer claims more lives than any other form of the disease.
Lung cancer is the third most common cancer in the United States, according to the Centers for Disease Control and Prevention, and takes the most lives of any cancer. In 2019, the latest year for which incidence data are available, 221,097 new cases of lung and bronchus cancer were reported in the U.S., and 139,601 people died from it, the CDC reports.
Those living in the most deprived areas are more than four times more likely to smoke than their most affluent counterparts.
Lead author Dr. Tomi Akinyemiju, of Duke University in North Carolina, said: "Our findings support that poverty is a fundamental cause of poor lung cancer outcomes."
The study linked lower income and education with a greater likelihood of advanced lung cancer diagnosis. It applied to patients of different ethnicities, those with government and private insurance and those treated at different types of health care facilities.
Early detection and treatment are key to combating lung cancer.
Akinyemiju and colleagues analyzed more than 1.3 million U.S. patients aged 18 to 89 using the 2004–2016 National Cancer Database. They had been diagnosed with any stage of non-small cell lung cancer. It's the most common type, accounting for almost 90 percent of cases.
The investigators also collected information on the education and income levels of the areas in which patients lived, as well as details on health insurance status and care.
They found only 17 percent of white patients were residents of areas in the lowest quarter for income - compared with 50 percent of black peers.
And just 18 percent were in areas with the highest proportion of adults without a high school education - compared with 44 percent.
Patients living in the lowest income and education areas were 13 and 12 percent more likely, respectively, to have advanced-stage lung cancer at the time of diagnosis.
These associations persisted among white, Black, Hispanic, and Asian patients, those with government and private insurance and those treated at any type of facility.
But Black patients in the highest education and income areas were more likely to have advanced-stage cancer than their white counterparts in the lowest education and income areas.
Akinyemiju said: "Strikingly, for Blacks, higher-income did not necessarily translate to better outcomes compared with whites.
"This highlights the urgent need for targeted efforts to ensure equitable access to smoking cessation and lung cancer screening, and additional research into other factors that drive lung cancer aggressiveness in Blacks."
Dr. Erica Warner, a cancer epidemiologist at Massachusetts General Hospital who was not involved in the study, said: "Segregation and concentration of non-Hispanic Black and other individuals of color in areas with greater poverty and lower educational attainment is not coincidental.
"As the authors acknowledge, these findings reflect the nature and impacts of structural racism."
She stressed the need for proactive, coordinated, community-engaged efforts to educate patients and clinicians, and to address patient and community barriers to improve screening, follow-up, and early recognition of lung cancer symptoms.
The study was published in the journal Cancer.
Uncommon Knowledge
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Newsweek is committed to challenging conventional wisdom and finding connections in the search for common ground.
